Rates of all substance-related ED visits from participating hospitals were highest among individuals with the following characteristics: males (2,668 per 100,000), individuals who were not Hispanic or Latino (2,391 per 100,000), and Black individuals, after accounting for the underlying population (4,053 per 100,000 versus 1,736 per 100,000 in the next highest subpopulation). The top substances reported were alcohol, cannabis, opioids, methamphetamines, cocaine, and benzodiazepines.