Over the past several decades, rising rates of substance misuse, substance use disorders (SUD), and related harms, including nonfatal and fatal overdoses, have placed a significant burden on individuals, communities, and the health care system. Expanding access to Preventing substance misuse, abuse, and addiction is one of the core strategic priorities for SAMHSA and aligns closely with the Make America Healthy Again initiative. Prevention is essential to avoid this chronic disease, and to improve public health. Integrating SUD prevention with physical health care is an effective strategy.